Computer controlled infusion of esmolol

Target Controlled Infusion (TCI)

The effect of perioperative esmolol infusion on the postoperative nausea, vomiting and pain after laparoscopic appendectomy

BACKGROUND Perioperative opioid administration results in postoperative nausea and vomiting (PONV) and acute opioid tolerance that manifests in increased postoperative pain. Esmolol is an ultra short acting cardioselective β1-adrenergic receptor antagonist, and it has been successfully used for perioperative sympatholysis and it reduces the opioid requirement during total intravenous anesthesia...

Computer-controlled heart rate increase by isoproterenol infusion: mathematical modeling of the system.

The purpose of this study was mathematical modeling of the heart rate (HR) response to isoproterenol (Iso) infusion. We developed a computerized system for the controlled increase of HR by Iso, based on a modified proportional-integral controller. HR was measured in conscious, freely moving rats. We found that the steady-state HR can be described as a hyperbolic power function of the steady-sta...

Prediction of infusion rates: computer study.

The administration of two test doses in the ratio 1:0.5 has been shown to provide sufficient data (time intervals) to predict the infusion rate necessary to maintain the concentration of a drug at the therapeutic threshold in a two-compartment pharmacokinetic model. If the relationship between the durations of action of the test doses is linear, only one test dose may be needed to predict the i...

[Intraoperative esmolol infusion reduces postoperative analgesic consumption and anaesthetic use during septorhinoplasty: a randomized trial].

BACKGROUND AND OBJECTIVES Esmolol is known to have no analgesic activity and no anaesthetic properties; however, it could potentiate the reduction in anaesthetic requirements and reduce postoperative analgesic use. The objective of this study is to evaluate the effect of intravenous esmolol infusion on intraoperative and postoperative analgesic consumptions as well as its effect on depth of ana...